Andy Murray and Emma Raducanu have both been knocked out of Wimbledon in the second round.
Two-time champion Murray lost in four sets as he was blown away by big-serving American John Isner on Centre Court.
Isner won their clash 6-4 7-6 6-7 6-4, helped by 36 aces.
It was the first time Murray had failed to reach the third round at SW19 as the 6ft 10in-tall US player secured his first career victory over him at the ninth attempt.
British fans suffered a double disappointment after Raducanu was earlier knocked out in the women’s singles.
The 19-year-old US Open champion was defeated by France’s Caroline Garcia who won in straight sets also on Centre Court 6-3 6-3.
But there was better news for British men’s number one Cameron Norrie who booked his place in the third round with a 6-4 3-6 5-7 6-0 6-2 win over Spaniard Jaume Munar.
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6ft 3in Murray had threatened another of his epic, late-night comebacks from two sets down when he won a third set tie-break.
But this time he was unable dip into that seemingly endless well of reserves as the American, 37, clung on for victory.
The 35-year-old Scot managed to win only 15 points against the relentless Isner first serve.
But there was so much more to the 20th seed’s triumph, with a host of neat drop shots and deft touches at the net leaving Centre Court stunned.
The roof was closed late on in the fourth set due to bad light with Isner leading 4-2.
The Briton’s preparations for this year’s Wimbledon had not been ideal after he suffered an abdominal strain a fortnight ago.
And the former world number one had faced a race against time to recover from the injury.
Meanwhile, Harriet Dart won her delayed first round match – becoming the 10th Briton to go through to round two – the best start to the Championships for home players since 1984.