Sajid Javid has resigned as health secretary and Rishi Sunak has stepped down as chancellor.
It came after Prime Minister Boris Johnson was forced to apologise over his handling of the Chris Pincher row, as it emerged that he had forgotten about being told of previous allegations of “inappropriate” conduct.
Politics live: ‘Very, very grave for Boris Johnson’ – double blow to PM’s future
But what about other cabinet members – will they stay or will they go?
Who has said they are staying:
• Housing Secretary Michael Gove
• Justice Secretary Dominic Raab, with a spokesperson saying Mr Raab is “loyal to the prime minister”
• Culture Secretary Nadine Dorries said: “I’m not sure anyone actually doubted this, however, I am 100% behind Boris Johnson, the PM who consistently gets all the big decisions right”
• Brexit opportunities minister Jacob Rees-Mogg said: “The prime minister won a large mandate in a general election, a vote of the British people and that should not be taken away from him because a number of people resign.”
• Scotland Secretary Alister Jack said he was “sorry to see good colleagues resign”, but “I fully support the prime minister”
• Business Secretary Kwasi Kwarteng
• Home Secretary Priti Patel
• Defence Secretary Ben Wallace
• International Trade Secretary Anne-Marie Trevelyan
• Attorney General Suella Braverman
• Foreign Secretary Liz Truss
• Wales Secretary Simon Hart
• Transport Secretary Grant Shapps
• Lord Privy Seal, and Leader of the House of Lords Baroness Evans
• Secretary of State at the Department for Work and Pensions Therese Coffey
Who hasn’t said whether they are staying or going?
• Education Secretary Nadhim Zahawi
• Environment Secretary George Eustice
• Northern Ireland Secretary Brandon Lewis
• Chief Secretary to the Treasury Simon Clarke
• Chief whip Chris Heaton-Harris
• Cabinet minister Alok Sharma
• Minister for Crime, Policing & Probation Kit Malthouse
• Minister of State for Higher and Further Education Michelle Donelan
• Cabinet Minister Michael Ellis
• Minister without portfolio Nigel Adams
• Lord President of the Council and Leader of the House of Commons Mark Spencer
Who else has said they are going:
As well as the chancellor and the health secretary, the following MPs have quit their posts:
• Trade envoy to Morocco, Andrew Murrison
• Bim Afolami has resigned as Tory vice chair
• Jonathan Gullis has resigned as parliamentary private secretary to the secretary of state for Northern Ireland
• Saqib Bhatti has resigned as parliamentary private secretary to the secretary of state for health